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Anne Hege Straume

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Chief Engineer/ Senior Engineer
Telephone: 45606329
Department: Reproduksjon og utviklingsbiologi

Publications

Academic articles

2023

In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.)

Mari Torsdotter Raudstein, Erik Nordtorp Kjærner-Semb, Morten Barvik, Silje Broll, Anne Hege Straume, Rolf Brudvik Edvardsen
Transgenic research
2021

Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors

Anne Hege Straume, Erik Nordtorp Kjærner-Semb, Kai Ove Skaftnesmo, Hilal Guralp, Simon Lillico, Anna Wargelius, Rolf Brudvik Edvardsen
BMC Genomics 22
2020

Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon

Hilal Guralp, Kai Ove Skaftnesmo, Erik Nordtorp Kjærner-Semb, Anne Hege Straume, Lene Kleppe, Rüdiger W. Schulz, Rolf Brudvik Edvardsen, Anna Wargelius
Scientific Reports 10
2020

The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer

Deepak Poduval, Zuzana Sichmanovà, Anne Hege Straume, Per Eystein Lønning, Stian Knappskog
PLOS ONE 15:e0225357 p. 1-23
2020

Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon

Anne Hege Straume, Erik Nordtorp Kjærner-Semb, Kai Ove Skaftnesmo, Hilal Guralp, Lene Kleppe, Anna Wargelius, Rolf Brudvik Edvardsen
Scientific Reports 10
2019

MYC-induced miR-203b-3p and miR-203a-3p control Bcl-xL expression and paclitaxel sensitivity in tumor cells

Sofia Aakko, Anne Hege Straume, Einar Elvbakken Birkeland, Ping Chen, Xi Qiao, Per Eystein Lønning, Marko J. Kallio
Translational Oncology 12 p. 170-179
2019

MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells.

Aakko S, Straume AH, Birkeland EE, Chen P, Qiao X, Lønning PE, Kallio MJ.
Transl Oncol. 12(1) p. 170-179
2016

Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel

Mahesh Balasaheb Tambe, Sofia Pruikkonen, Jenni Heidi Eveliina Mäki-Jouppila, Ping Chen, Bente Vilming Elgaaen, Anne Hege Straume, Kaisa Huhtinen, Olli Carpén, Per Eystein Lønning, Ben Davidson, Sampsa Hautaniemi, Marko Johannes Kallio
OncoTarget 7 p. 12267-12285
2016

Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to

Tambe M, Pruikkonen S, Mäki-Jouppila J,Chen P, Vilming Elgaaen B, Straume AH, Huhtinen K, Cárpen O, Lønning PE, Davidson B, Hautaniemi S, Kallio MJ
Oncotarget
2014

Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue

Anne Hege Straume, Stian Knappskog, Per Eystein Lønning
Journal of Steroid Biochemistry and Molecular Biology 143 p. 192-198
2014

Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue

Anne Hege Straume, Stian Knappskog, Per Eystein Lønning
J Steroid Biochem Molec Biol; 18:143C p. 192-198
2012

Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women

Anne Hege Straume, Stian Knappskog, Per Eystein Lønning
Journal of Steroid Biochemistry and Molecular Biology 128 p. 69-75
2012

Elevated levels of the steroidogenic factor 1 are associated with over-expression of CYP19 in an oestrogen-producing testicular Leydig cell tumour

Anne Hege Straume, Kristian Løvås, Hrvoje Miletic, Karsten Gravdal, Per Eystein Lønning, Stian Knappskog
European Journal of Endocrinology (EJE) 166 p. 941-949
2012

Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Oestrogen producing testicular Leydig cell tumour

European Journal of Endocrinology 166 p. 941-949
2012

Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women

Straume AH, Knappskog S, Lønning PE
J Steroid Biochem Molec Biol; 128(1-2) p. 69-75
2011

Exploring breast cancer estrogen disposition: The basis for endocrine manipulation

Per Eystein Lønning, Ben P. Haynes, Anne Hege Straume, Anita Dunbier, Hildegunn Helle, Stian Knappskog, Mitch Dowsett
Clinical Cancer Research 17 p. 4948-4958
2011

Recent data on intratumor estrogens in breast cancer

Per Eystein Lønning, Ben P. Haynes, Anne Hege Straume, Anita Dunbier, Hildegunn Helle, Stian Knappskog, Mitch Dowsett
Steroids 76 p. 786-791
2011

Recent data on intratumor estrogens in breast cancer

Steroids 76 p. 786-791
2011

Exploring breast cancer estrogen disposition: the basis for endocrine manipulation.

Clin Cancer Res 17 p. 4948-4958
2010

Intratumoral estrogen disposition in breast cancer

Ben P. Haynes, Anne Hege Straume, Jurgen Geisler, Roger A'Hern, Hildegunn Helle, Ian E Smith, Per Eystein Lønning, Mitch Dowsett
Clinical Cancer Research 16 p. 1790-1801
2010

Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity

Elisabet Ognedal Berge, Vidar Staalesen, Anne Hege Straume, Johan R. Lillehaug, Per Eystein Lønning
BBA - Molecular Cell Research 1803 p. 386-395
2010

Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity

Biochim Biophys Acta 1803 p. 386-396
2010

Intratumoral estrogen disposition in breast cancer

Clin Cancer Res 16 p. 1790-1801
2006

Analysing the outer membrane subproteome of Methylococcus capsulatus (Bath) using proteomics and novel biocomputing tools

Frode Berven, Odd Andre Karlsen, Anne Hege Straume, Kristian Flikka, J. Collin Murrell, Anne Fjellbirkeland, Johan Lillehaug, Ingvar Eidhammer, Harald B Jensen
Archives of Microbiology 184 p. 362-377
2006

Analysing the outer membrane subproteome of Methylococcus capsulatus (Bath) using proteomics and novel biocomputing tools

Arch Microbiol 184 p. 362-377

Other journal contributions

2021

Author Correction: Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon (Scientific Reports, (2020), 10, 1, (18042), 10.1038/s41598-020-74876-2)

Hilal Güralp, Kai Ove Skaftnesmo, Erik Nordtorp Kjærner-Semb, Anne Hege Straume, Lene Kleppe, Rüdiger W. Schulz, Rolf Brudvik Edvardsen, Anna Wargelius
Scientific Reports 11
2009

DETERMINANTS OF INTRATUMOURAL OESTRADIOL (E2) CONCENTRATIONS IN POSTMENOPAUSAL BREAST CANCER: ROLES FOR OESTROGEN RECEPTOR (ER) AND 17B-HYDROXYSTEROID DEHYDROGENASE 7 (HSD17B7)

B Haynes, Anne Hege Straume, Jurgen Geisler, R Ahern, Per Eystein Lønning, PE Lonning, M Dowsett
Annals of Oncology 20 p. 51-52

Scientific lectures

2019

Highly efficient CRISPR/Cas9 knock-in in Atlantic salmon

Rolf Brudvik Edvardsen, Anne Hege Straume, Erik Nordtorp Kjærner-Semb, hilal guralp, Lene Kleppe, Kai Ove Skaftnesmo, Anna Wargelius
2019

Highly efficient CRISPR/Cas9 knock-in in Atlantic Salmon

Anne Hege Straume, hilal guralp, Kai Ove Skaftnesmo, Anna Wargelius, Rolf Brudvik Edvardsen
2018

Optimization of CRISPR/Cas9 knock-in technology and application in salmon

Rolf Edvardsen, Anne Hege Straume, Kai Ove Skaftnesmo, Lene Kleppe, hilal guralp, Anna Wargelius

Reports and dissertations

2012

A genetic perspective on estrogen metabolism in cancer: The potential role of alterations affecting CYP19, 17β-HSD2 and 17β-HSD7

Straume, Anne Hege
2004

Methylococcus capsulatus (Bath); Molecular analyses of a surface exposed heteromultimeric protein complex

Anne Hege Straume, Harald B Jensen, Frode Berven, Johan Lillehaug
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