Eystein Oveland

Employment

2022 Aug –                  Executive director. Nordic-Baltic Committee on Food Analysis (NMKL).

2020 – 2021                Secretary General. Nordic Committee on Food Analysis (NMKL).

2018 Jan –                   Senior Scientist (Research professor 1183). Institute of Marine Research (IMR).

2020 Nov - 2022        Secretary General. Nordic Committee on Food Analysis (NMKL).

2016 – 2017                Senior Scientist (Research professor 1183 from 2017). The National Institute of Nutrition and Seafood Research (NIFES).

2012 – 2016                Researcher (1109). The Department of Clinical Medicine (K1) and the Proteomics Unit at the University of Bergen (PROBE), Department of Biomedicine (IBM), Faculty of medicine and Dentistry (MOFA), University of Bergen (UiB): ”Identification of biomarkers to define the cause of multiple sclerosis”.

2011 – 2012                Researcher (1109). PROBE, UiB, 3 months.

2008 – 2011                Post Doc. Project: “The extracellular microenvironment”, the Cardiovascular Research Group, IBM, MOFA, UiB.

2003 – 2004               Researcher. PROBE, UiB.

2002 – 2003                Researcher. UniTargetingResearch AS (R&D), 50-100%.

Education

2004 – 2008                PhD, thesis: “Modulation of apoptosis by the receptor tyrosine kinase Flt3 in acute myeloid leukemia cells”, Institute for Biomedicine/Proteomics Unit, Faculty of Medicine, University of Bergen.

2000 – 2003                Cand. scient. (Master degree), thesis: "The use of marine luciferases in a study aiming at the secretion of intracellular proteins from mammalian cells", the Department of Molecular Biology, UiB.

1996 – 1999                Høgskolekandidat (Bachelor), thesis: ”Mikrotubers on potato plants; induction conditions, regeneration ability and genetic transformation”, The Biotechnology Section, Hedmark University College.

Commissions

2023 Feb –                  MicroVal, General Committee Member.

2022 Feb –                  AOAC Europe, Board member.

2021 Jan –                   NordVal International, Technical Committee and Steering Group member.

2017 Feb –                  Comitè Europeèn de Normalisation (CEN) Technical Committee (TC) Working Group (WG) Analytical Standards on Vitamins (CEN/TC 275/WG 9). Expert member.

2017 Feb –                  ISO/TC/WG 14 Vitamins, carotenoids and other nutrients. Expert member.

2017 Feb –                  AOAC International (member), participate in stakeholder and expert review panel meetings on multi laboratory testing for analytical methods for vitamins.

2009 – 2011                Representative for temporary scientific employees in the institute council at IBM, UiB.

2007 – 2008                Representative for temporary scientific employees in the institute research council at IBM, UiB.

2006 – 2007                Representative for temporary scientific employees in the faculty research council, MOFA, UiB.

Peer-reviewed publications (35)

Skjærven KH, Mommens M, Adam AC, Saitoa T, Oveland E, Espe M. Earlier or delayed seasonal broodstock spawning changes nutritional status and metabolic programming of growth for next-generation Atlantic salmon. Aquaculture, 2022.

Madhushri SV, Belgith I, Gjerde J, Plamblad M, Oveland E, Rasinger JD. Shotgun proteomics approaches for authentication, biological analyses, and allergen detection in feed and food-grade insect species. Food Control, 2022.

Jensen MB, Rød KE, Švarc PL, Oveland E, Jakobsen J. Vitamin K (phylloquinone and menaquinones) in foods - Cost-effective quantification by LC-ESI-MS/MS. Food Chemistry, 2022.

Ahmad I, Wergeland S, Oveland E, Bø L. A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination. PLoS One, 2021.

Lecrenier MC, Marien A, Veys P, Belghit I, Dieu M, Gillard N, Henrottin J, Herfurth UM, Marchis D, Morello S, Oveland E, Poetz O, Rasinger JD, Steinhilber A, Baeten V, Berben G, Fumière O. Inter-laboratory study on the detection of bovine processed animal protein in feed by LC-MS/MS-based proteomics. Food Control, 2021.

Khramova A, Boi R, Fridén V, Granqvist AB, Nilsson U, Tenstad O, Oveland E, Haraldsson B, Ebefors K, Nyström J. Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease. Scientific Reports, 2021.

Oveland E, Ahmad I, Lereim RR, Kroksveen AC, Barsnes H, Guldbrandsen A, Myhr KM, Bø L, Berven FS, Wergeland S. Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis. Scientific Reports, 2021.

Ložnjak Švarc P, Oveland E, Strandler HS, et al. Collaborative study: Quantification of total folate in food using an efficient single-enzyme extraction combined with LC-MS/MS. Food Chemistry, 2020.

Skjærven KH, Oveland E, Mommens M, Samori E, Saito T, Adam AC, Espe M. Out-off season spawning affects the nutritional status and gene expression in both Atlantic salmon female broodstock and their offspring. Comp Biochem Physiol A Mol Integr Physiol, 2020.

Nystad AE, Reehorst Lereim R, Wergeland S, Oveland E, Myhr KM, Bø L, Torkildsen Ø. Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model. J. Neuroimmunology, 2019.

Berle M, Ghila L, Vethe H, Chaudhry A, Garberg H, Beisland C, Haaland ØA, Oveland E, Halvorsen OJ, Davidsson T, Chera S. Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLoS One, 2018.

Oveland E, Nystad A, Berven F, Myhr KM, Torkildsen Ø, Wergeland S. 1,25-Dihydroxyvitamin-D3 induces brain proteomic changes in cuprizone mice during remyelination involving calcium proteins. Neurochem Int., 2018.

Bjørkum AA, Oveland E, Stuhr L, Havnes MB, Berven F, Grønning M, Hope A. Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats. PLoS One, 2017.

Nygaard G, Herfindal L, Asrud KS, Bjørnstad R, Kopperud RK, Oveland E, Berven FS, Myhren L, Hoivik EA, Lunde THF, Bakke M, Døskeland SO, Selheim F. Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Report, 2017.

Yadetie F, Oveland E, Døskeland A, Berven F, Goksøyr A, Karlsen OA. Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153. Aquat Toxicol, 2017.

Guldbrandsen A, Farag Y, Kroksveen AC, Oveland E, Lereim RR, Opsahl JA, Myhr KM, Berven FS, Barsnes H. CSF-PR 2.0: an interactive literature guide to quantitative cerebrospinal fluid mass spectrometry data from neurodegenerative disorders. Molecular & Cellular Proteomics, 2017.

Lereim RR, Oveland E, Berven FS, Vaudel M, Barsnes H. Visualization, Inspection and Interpretation of Shotgun Proteomics Identification Results. Adv Exp Med Biol, 2016.

Lereim RR* and Oveland E*, Xiao Y, Torkildsen Ø, Wergeland S, Myhr KM, Sun SC, Berven FS. The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis. J Proteomics Bioinformatics, 2016. *Contributed equally.

Yadetie F, Bjørneklett S, Garberg HK, Oveland E, Berven F, Goksøyr A, Karlsen OA. Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism. BMC Genomics, 2016.

Vaudel M, Burkhart J, Zahedi RP, Oveland E, Berven FS, Sickmann A, Martens L, Barsnes H. PeptideShaker: Completing the proteomics data cycle. Nature Biotechnology, 2015.

Haslene-Hox H, Oveland E, Woie K, Salvesen HB, Tenstad O, Wiig H. Distribution volume of macromolecules in human ovarian and endometrial cancers - effects of extracellular matrix structure. American journal of physiology Heart and circulatory physiology, 2015.

Sagstad SJ, Oveland E, Karlsen TV, Haslene-Hox H, Tenstad O, Wiig H. Age-Related Changes in Rat Dermal Extracellular Matrix Composition Affect the Distribution of Plasma Proteins as a Function of Size and Charge. American journal of physiology Heart and circulatory physiology, 2015.

Oveland E, Muth T, Rapp E, Martens L, Berven FS og Barsnes H. Viewing the Proteome: How to Visualize Proteomics Data? Proteomics, 2015.

Kroksveen AK, Opsahl JA, Guldbrandsen A, Myhr KM, Oveland E, Torkildsen Ø, Berven F. Cerebrospinal fluid proteomics in multiple sclerosis. BBA - Proteins and Proteomics, 2014.

Guldbrandsen A, Vethe H, Farag Y, Oveland E, Garberg H, Berle M, Myhr KM, Opsahl JA, Barsnes H, Berven FS. In-depth characterization of the cerebrospinal fluid proteome displayed through the CSF Proteome Resource (CSF-PR). Molecular & Cellular Proteomics, 2014.

Haslene-Hox H* and Oveland E*, Woie K, Salvesen HB, Wiig H, Tenstad O. Increased WD-repeat containing protein 1 in interstitial fluid from ovarian carcinomas shown by comparative proteomic analysis of malignant and healthy gynecological tissue. Biochim Biophys Acta, 2013. *Contributed equally.

Oveland E, Karlsen TV, Haslene-Hox H, Semaeva E, Janaczyk B, Tenstad O, Wiig H. Proteomic Evaluation of Inflammatory Proteins in Rat Spleen Interstitial Fluid and Lymph during LPS-Induced Systemic Inflammation Reveals Increased Levels of ADAMST1. J Proteome Res, 2012.

Oveland E, Wergeland L, Hovland R, Lorens JB, Gjertsen BT, Fladmark KE. Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. Cell Biol Toxicol, 2012.

Haslene-Hox H, Oveland E, Berg KC, Kolmannskog O, Woie K, Salvesen HB, Tenstad O, and Wiig H. A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissue. PLoS One 6: e19217, 2011.

Friden V, Oveland E, Tenstad O, Ebefors K, Nystrom J, Nilsson UA, and Haraldsson B. The glomerular endothelial cell coat is essential for glomerular filtration. Kidney Int, 2011.

Berle M, Kroksveen AC, Haaland OA, Aye TT, Opsahl JA, Oveland E, Wester K, Ulvik RJ, Helland CA, and Berven FS. Protein profiling reveals inter individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid. Fluids Barriers CNS 8: 19, 2011.

Brekke HK, Oveland E, Kolmannskog O, Hammersborg SM, Wiig H, Husby P, Tenstad O, and Nedrebo T. Isolation of interstitial fluid in skin during volume expansion: evaluation of a method in pigs. Am J Physiol Heart Circ Physiol 299: H1546-1553, 2010.

Oveland E, Gjertsen BT, Wergeland L, Selheim F, Fladmark KE, and Hovland R. Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Leuk Res 33: 276-287, 2009.

Birkeland E, Nygaard G, Oveland E, Mjaavatten O, Ljones M, Doskeland SO, Krakstad C, and Selheim F. Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of proteomics and bioinformatics 02: 244, 2009.

Oveland E, Fladmark KE, Wergeland L, Gjertsen BT, and Hovland R. Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies. Curr Pharm Biotechnol 7: 185-198, 2006.

Reports

Hamre K, Remø S, Ørnsrud R, Oveland E, Merel S, Waagbø R, Micallef G, Hillestad M, Johansen J. Oksidativt stress, vårdropp i pigmentering og produksjonslidelser hos laks. Rapport fra Havforskningen Nr. 2019-16, 2019.  

Logemann J, Oveland E, Bjorøy Ø, Peters W, Cojocariu C, Kögel T. Pyrolysis-GC-Orbitrap MS - a powerful analytical tool for identification and quantification of microplastics in a biological matrix. Technical Note, Thermo Scientific, 2018.

Popular science articles

Lereim RR, Oveland E, Myhr KM. Peli1 i immunregulering ved multippel sklerose. BestPractice Faglig dialog mellom leger, norsk versjon. Akseptert for publikasjon. Ref. Lars Christensen, lc@bestprac.dk. Norsk vitenskapelig, 2017.

Grytten Torkildsen N, Oveland E. Bedre visualisering av proteinanalyser og nytt bioinformatisk verktøy bidrar til medisinsk forskning. Kristian Gerhard Jebsen senter for MS-forsknings hjemmeside, Universitetet i Bergen, 2015.

Book chapter

Smith R, Stern B, Gjerdrum C, Knappskog S, Minsaas L, Nylund S, Olsen L, Olsen L, Oveland E, Ravneberg H, Trösse C, Tveit A, Vollsund E, Hesketh J, Tauler A, and Pryme I. UTRtech™: Exploiting mRNA Targeting To Increase Protein Secretion From Mammalian Cells. In: Cell Technology for Cell ProductsSpringer Netherlands, 2007, p. 261-268.

Peer review for journals

Marine Pollution Bulletin (2020), BJN (2019), Brain (2016), Oncotarget (2016), Proteomics (2014), PLOS ONE (2014, 2013), Cell Biology and Toxicology (2011), Current Pharmaceutical Biotechnology (2006).

Presentations at scientific meetings

Vitamin Conference, Copenhagen, Denmark. Poster and presentation: “UHPLC-MS/MS determination of total folate by quantification of 6 vitamers -current challenges. Oveland E, Petrova SM, Myhra T, Bøkevoll A, Waagbø R. 2021.

Norske Seminar i Massespektrometri Bi-annual Meeting, Hafjell. Poster: “Quantification of Folates in Salmon using UHPLC-MS/MS”. Oveland E, Hageskal R, Wollertsen N, Mommens M, Waagbø R, Skjaerven KH. 2019. Poster prize.

AOAC Annual Meeting, Toronto, Canada. Poster: “Salmon Production and Quantification of Folates Using AOAC Trienzyme UPLC-MS/MS Method”. Oveland E, Hageskal R, Samori E, Wollertsen N, Mommens M, Waagbø R, Skjaerven KH. 2018.

AOAC Annual Meeting , Atlanta, USA. Poster: “Method development and analysis of vit K (phylloquinone and menaquinones) in selected foods”. Oveland E, Rød KE, Bøkevoll A, Dahl L, Hamre K, Waagbø R. 2017.

AOAC SPIFAN and ISO WG 14 Midyear Meeting, Gaithersburg, Maryland, USA. Representant for Standard Norge: stemmerett i ISO WG 14. 2017.

HUPO 12th Annual World Congress, Yokohama, Japan: Poster: “TMT and label-free differential brain proteome analysis of two multiple sclerosis models in mice and verification in patients”. Oveland E, Wergeland S, Barsnes H, Myhr KM, Bø L, Berven FS. 2013.

61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis: Poster: “TMT and label-free differential brain proteome analysis of two multiple sclerosis models in mice and verification in patients”. Oveland E, Wergeland S, Barsnes H, Myhr KM, Bø L, Berven FS. 2013.

8th National Proteomics Meeting, Oslo. Talk: “Comparison of cuprizone and experimental autoimmune encephalomyelitis multiple sclerosis models using TMT and label-free quantitative proteomics and translation to patients”. Oveland E. 2013.

Proteomic Forum 2011, Berlin. Poster: “Measurement of Glomerular Sieving of Plasma Proteins in Rats Using Mass Spectrometry”. Wallace PW, Oveland E, Tenstad O. 2011.

3rd Norforsk Proteomics Meeting, Dundee, Scotland. Talk: “SILAC enabled identification of regulated apoptosis-associated proteins in leukemia cells exposed to ligand-induced downregulation of the Flt3 receptor tyrosine kinase”. Oveland E. 2008.

Project lead

2017 – 2022                Vitaminomics (IMR 15273).

2020 – 2024                NMKL-HI (IMR 15684).

2018 – 2019                Metodeutvikling Nansen, prøvebehandling og lagring (15285).

2012 – 2016                Brain tissue proteomics project, KG Jebsen Centre for Multiple Sclerosis Research, Department of Clinical Medicine, UiB.

2008 – 2011                Ovarian cancer and tissue physiology proteomics and mass spectrometry projects, Heart and Circulatory research group, UiB.

Supervision of students

2013 –                          Co-supervisor PhD student: “Proteomics and immunohistochemistry to detect lesion stage markers in multiple sclerosis”, Ahmad IM, MOFA, UiB.

2016 – 2021                Co-supervisor PhD student: “Using meta-analyses of proteomics data to identify novel disease networks in multiple sclerosis”, Lereim RR, MOFA, UiB.

2013 – 2014                Main supervisor master student: “Proteomics of human brain and CSF to detect biomarkers in multiple sclerosis” Reehorst Lereim R, MOFA, UiB. Grade: A.

2009 – 2013                Co-supervisor PhD student: “The microenvironment in human ovarian carcinoma – characterization through proteomic analysis of tissue interstitial fluid”, Haslene-Hox H, MOFA, UiB.

2010 – 2011                Co-supervisor master student: “Proteinuria: A new approach to understand glomerular barrier function using quantitative proteomics”, Wallace PW, MOFA, UiB. Grade: A.

2009 – 2010                Co-supervisor medical Student Research Programme students: ”Identification of tumor-specific proteins in ovarian cancer”, Sværen MK and Naterstad IK, MOFA, UiB.

2005 – 2006                Co-supervisor master student: ”Approaches to discover members of the oncogenic Flt3 receptor tyrosine kinase signaling network”, Hodneland LI, MOFA, UiB. Grade: B.

University examiner and teaching experience

2020                              External examiner master degree: Chemistry Department, UiB.

2020                              External examiner master degree: Centre for International Health Department of Global Health and Primary Care, UiB.

2017 – 19                    External examiner (3 times): Biomedical Nutrition Physiology (BMED 381), IBM, UiB.

2006 – 08                    Assistant teacher: medical students in particular subjects in Histology (1^st year) and Anatomy (2^nd year), MOFA, UiB.

2005 – 06                    Teacher and subject responsible (2 times): HUCEL 370 Apoptose, MOFA, UiB.

2003 spring                 Teacher and course responsible: “DNA- exercise”, Laboratory course for medical students, MOFA, UiB.

Organizer of meetings

2022                              NMKL Annual meeting as joint physical and virtual, Finland.

2021                              NMKL Annual meeting as joint physical and virtual, Norway.

2019                              CEN/TC 275/WG 9 and ISO/TC/WG 14 joint meeting hosted by IMR, Bergen, Norway.

2014 – 2015                Bioinformatics for Proteomics 4-day course, PROBE, Bergen. Member of organizing committee 2014 and 2015.