Elisabeth Holen

Forsker

E-post: Elisabeth.Holen@hi.no

Telefon: 95241633

Avdeling: Behov og velferd

Publikasjoner

Publikasjoner

Faglige foredrag

2018

Effekter av resveratrol på lipo-polysakkarid indusert transkripsjon av immungener og eikosanoidsekresjon i atlantisk laks, ved bruk av forskjellige cellemodeller.

Elisabeth Holen, Pedro Araujo, S Xie, Liv Ingeborg Rosvoll Søfteland, Marit Espe

2016

In Vitro Fisk: Nye 3D modeller til ernæring og toksikologisk forskning.

Liv Ingeborg Rosvoll Søfteland, Elisabeth Holen, Marit Espe, Pål Asgeir Olsvik

2014

Kan arginintilsetning påvirke forbrenning av visceralt fett gjennom økt polyaminomsetning i laks?

Synne Marte Andersen, Elisabeth Holen, Ivar Rønnestad, Jan Erik Zerrahn, Richard Taylor, Anders Aksnes, Marit Espe

2013

Do diets with 1-5% EPA and DHA induce inflammation in Atlantic salmon?

Nina Sylvia Liland, Elisabeth Holen, Bente Elisabeth Torstensen, Nini Sissener, Grethe Rosenlund

2000

Allergimedisin svekker ikke immunforsvaret

Elisabeth Holen, Thien van Do, Said Elsayed

Vitenskapelige artikler (NVI)

2019

Effect of dietary replacement of fish meal with insect meal on in vitro bacterial and viral induced gene response in Atlantic salmon (Salmo salar) head kidney leukocytes

Oda Kvalsvik Stenberg, Elisabeth Holen, Luisa Piemontese, Nina Sylvia Liland, Erik-Jan Lock, Marit Espe, Ikram Belghit

Fish and Shellfish Immunology 91 p. 223-232

2019

The effect of omega-3 and omega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cells

Pedro Araujo, Ikram Belghit, Niels Aarsaether, Marit Espe, Eva Lucena, Elisabeth Holen

Nutrients 11:966 p. 1-18

2019

Development of a fatty liver model using oleic acid in primary liver cells isolated from Atlantic salmon and the prevention of lipid accumulation using metformin

Marit Espe, Shiwei Xie, Shijun Chen, Pedro Araujo, Elisabeth Holen

Aquaculture Nutrition 25 p. 737-746

2019

Surplus arginine reduced lipopolysaccharide induced transcription of proinflammatory genes in Atlantic salmon head kidney cells

Graciela P Martins, Marit Espe, Zhihao Zhang, Igo Gomes Guimarães, Elisabeth Holen

Fish and Shellfish Immunology 86 p. 1130-1138

2018

A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes

Elisabeth Holen, Pedro Araujo, Nini Sissener, Grethe Rosenlund, Rune Waagbø

Fish and Shellfish Immunology 72 p. 57-68

2017

Choline supplementation increased total body lipid gain, while surplus methionine improved growth and amino acid retention in adult Atlantic salmon (Salmo salar)

Marit Espe, Synne Marte Andersen, Eva Veiseth-Kent, Ivar Rønnestad, Elisabeth Holen, Jens-Erik Zerrahn, Anders Aksnes

Aquaculture Nutrition 23 p. 1086-1094

2017

Phytosterols are not involved in the development of fatty liver in plant oil fed Atlantic salmon (Salmo salar) at high or low water temperature

Nini Sissener, Nina Sylvia Liland, Elisabeth Holen, Ingunn Stubhaug, Bente Elisabeth Torstensen, Grethe Rosenlund

Aquaculture 480 p. 123-134

2016

Choline supplementation to low methionine diets increase phospholipids in Atlantic salmon, while taurine supplementation had no effects on phospholipid status, but improved taurine status

Marit Espe, Jens-Erik Zerrahn, Elisabeth Holen, Ivar Rønnestad, Eva Veiseth-Kent, Anders Aksnes

Aquaculture Nutrition 22 p. 776-785

2016

β-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B₄ secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation

Elisabeth Holen, Pål Asgeir Olsvik

Fish and Shellfish Immunology 54 p. 128-134

2016

Hydrolyzed fish proteins modulates both inflammatory and antioxidant gene expression as well as protein expression in a co culture model of liver and head kidney cells isolated from Atlantic salmon (Salmo salar)

Elisabeth Holen, Juyun He, Pedro Araujo, Jørgen Seliussen, Marit Espe

Fish and Shellfish Immunology 54 p. 22-29

2015

Adult Atlantic salmon (Salmo salar L.) adapts to long-term surplus dietary arginine supplementation

Synne Marte Andersen, Elisabeth Holen, Anders Aksnes, Ivar Rønnestad, Jens-Erik Zerrahn, Marit Espe

Aquaculture Nutrition 21 p. 355-363

2015

Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells invitro

Elisabeth Holen, Juyun He, Marit Espe, Liqiou Chen, Pedro Araujo

Fish and Shellfish Immunology 45 p. 695-703

2015

Hydrolyzed fish proteins reduced activation of caspase-3 in H 2 O 2 induced oxidative stressed liver cells isolated from Atlantic salmon (Salmo salar)

Marit Espe, Elisabeth Holen, Juyun He, Fiona Provan, Liqiao Chen, Kjell Birger Øysæd, Jørgen Seliussen

SpringerPlus 4

2014

The impact of exogenous ω-6 and ω-3 polyunsaturated fatty acids on the induced production of pro- and anti-inflammatory prostaglandins and leukotrienes in Atlantic salmon head kidney cells using a full factorial design and LC-MS/MS

Pedro Araujo, Eva Lucena, Yang Yang, Bupesh Ceemala, Zebasil Tassew Mengesha, Elisabeth Holen

Journal of chromatography. B 964 p. 164-171

2014

A co culture approach show that polyamine turnover is affected during inflammation in Atlantic salmon immune and liver cells and that arginine and LPS exerts opposite effects on p38MAPK signaling

Elisabeth Holen, Marit Espe, Synne Marte Andersen, Richard Taylor, Anders Aksnes, Zebasil Tassew Mengesha, Pedro Araujo

Fish and Shellfish Immunology 37 p. 286-298

2014

Arginine supplementation and exposure time affects polyamine and glucose metabolism in primary liver cells isolated from Atlantic salmon

Synne Marte Andersen, Richard Taylor, Elisabeth Holen, Anders Aksnes, Marit Espe

Amino Acids 46 p. 1225-1233

2014

Aryl hydrocarbon receptor protein and Cyp1A1 gene induction by LPS and phenanthrene in Atlantic cod (Gadus morhua) head kidney cells

Elisabeth Holen, Pål Asgeir Olsvik

Fish and Shellfish Immunology 40 p. 384-391

2014

Methionine deficiency does not increase polyamine turnover through depletion of hepatic S-adenosylmethionine in juvenile Atlantic salmon

Marit Espe, Synne Marte Andersen, Elisabeth Holen, Ivar Rønnestad, Eva Veiseth-Kent, Jens-Erik Zerrahn, Anders Aksnes

British Journal of Nutrition 112 p. 1274-1285

2013

Cytokine gene expression and prostaglandin production in head kidney leukocytes isolated from Atlantic cod (Gadus morhua) added different levels of arachidonic acid and eicosapentaenoic acid

Miriam Furné Castillo, Elisabeth Holen, Pedro Araujo, Kai Kristoffer Lie, Mari Moren

Fish and Shellfish Immunology 34 p. 770-777

2013

Taurine attenuates apoptosis in primary liver cells isolated from Atlantic salmon (Salmo salar)

Marit Espe, Elisabeth Holen

British Journal of Nutrition 110 p. 20-28

2013

Dietary arginine affects energy metabolism through polyamine turnover in juvenile Atlantic salmon (Salmo salar)

Synne Marte Andersen, Elisabeth Holen, Anders Aksnes, Ivar Rønnestad, Jens-Erik Zerrahn, Marit Espe

British Journal of Nutrition 110 p. 1968-1977

2012

Low impact of exposure to environmentally relevant doses of Ra-226 in Atlantic cod (Gadus morhua) embryonic cells

Pål Asgeir Olsvik, Marc Berntssen, Ketil Hylland, Dag Ø. Eriksen, Elisabeth Holen

Journal of Environmental Radioactivity 109 p. 84-93

2012

Pathogen recognition and mechanisms in Atlantic cod (Gadus morhua) head kidney cells Bacteria (LPS) and virus (poly I:C) signals through different pathways and affect distinct genes

Elisabeth Holen, Kai Kristoffer Lie, Hernandez Pedro W. Araujo, Pål Asgeir Olsvik

Fish and Shellfish Immunology 33 p. 267-276

2012

Application of Doehlert uniform shell designs for selecting optimal amounts of internal standards in the analysis of prostaglandins and leukotrienes by liquid chromatography-tandem mass spectrometry

Hernandez Pedro W. Araujo, Steve Janagap, Elisabeth Holen

Journal of Chromatography A 1260 p. 102-110

2011

Inhibition of p38 MAPK during cellular activation modulate gene expression of head kidney leukocytes isolated from Atlantic salmon (Salmo salar) fed soy bean oil or fish oil based diets

Elisabeth Holen, Synnøve Winterthun, ZHEN-YU DU, Anne Vatland Krøvel

Fish and Shellfish Immunology 30 p. 397-405

2011

Ontogenetic expression of maternal and zygotic genes in Atlantic cod embryos under ambient and thermally stressed conditions

Kaja Helvik Skjærven, Pål Asgeir Olsvik, Roderick Nigel Finn, Elisabeth Holen, Kristin Hamre

Comparative Biochemistry and Physiology A 159 p. 196-205

2011

Development of a co-culture model for in vitro toxicological studies in Atlantic salmon

Anne Vatland Krøvel, Synnøve Winterthun, Elisabeth Holen, Pål Asgeir Olsvik

Toxicology in Vitro 25 p. 1143-1152

2011

Transcriptional evidence for low contribution of oil droplets to acute toxicity from dispersed oil in first feeding Atlantic cod (Gadus morhua) larvae

Pål Asgeir Olsvik, Bjørn Henrik Hansen, Trond Nordtug, Mari Moren, Elisabeth Holen, Kai Kristoffer Lie

154 p. 333-345

2010

Embryonic stem cells isolated from Atlantic cod (Gadus morhua) and the developmental expression of a stage-specific transcription factor ac-Pou2

Elisabeth Holen, Anette Kausland, Kaja Helvik Skjærven

36 p. 1029-1039

2010

Toxicological application of primary hepatocyte cell cultures of Atlantic cod (Gadus morhua) - Effects of BNF, PCDD and Cd

Liv Ingeborg Rosvoll Søfteland, Elisabeth Holen, Pål Asgeir Olsvik

151 p. 401-411

2007

Pigmentation and eye-migration in Atlantic halibut (Hippoglossus hippoglossus L.) larvae: Relevance of knowledge on development of pigment cells and determination of body axes in vertebrates.

Kristin Hamre, Elisabeth Holen, Mari Moren

Aquaculture Nutrition 13 p. 65-80

2005

Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion

Elisabeth Holen, Oddvin Anton Bjørge, Roland Jonsson

Nutrition Research 21 p. 1003-1009

2004

Dietary nucleotides and intestinal cell lines: I. Modulation of growth

Elisabeth Holen, Roland Jonsson

Nutrition Research 24 p. 197-207

1999

Horfor øker hyppigheten av allergi i industrialiserte land mer enn i utviklingsland?

Elisabeth Holen, Said Elsayed

? 119 p. 3176-3177

1999

Evaluating B and T cell epitopes of ovomucoid: Intact modified molecules, CNBr fragments and synthetic peptides

Said Elsayed, Elisabeth Holen

Allergy. European Journal of Allergy and Clinical Immunology 54 p. 211

1999

Characterization of T cell response to a-lactalbumin in PMMC cultures from cow mild hypersensitivity adults

Said Elsayed, Elisabeth Holen

Allergy. European Journal of Allergy and Clinical Immunology 54 p. 422

Annet tidsskriftbidrag

2013

Enhanced polyamine turnover after arginine supplementation in an Atlantic salmon model-implications on growth and animal welfare

Synne Marte Andersen, Elisabeth Holen, Anders Aksnes, Ivar Rønnestad, Jens-Erik Zerrahn, Marit Espe

Amino Acids 45 p. 575-576

2013

Methionine limitation-a threat to health? Using Atlantic salmon as the model

Marit Espe, Synne Marte Andersen, Elisabeth Holen, Jens-Erik Zerrahn, Ivar Rønnestad, E. Veiseth, Anders Aksnes

Amino Acids 45 p. 591-591

Rapporter og avhandlinger

2016

Effekter av endret fettsyresammensetning i fôr til laks relatert til fiskens helse, velferd og robusthet (Fett for fiskehelse): Oppdatering 2016

Nini Sissener, Bente Elisabeth Torstensen, Bente Ruyter, Tone-Kari K Østbye, Rune Waagbø, Sven Martin Jørgensen, Bjarne Hatlen, Nina Sylvia Liland, Elisabeth Ytteborg, Øystein Sæle, Ida Rud, Sofie C. Remø, Turid Mørkøre, Jens-Erik Dessen, Kaja Skjerven, Trine Ytrestøyl, Elisabeth Holen, Gerd Marit Berge, Anne-Catrin Adam

2007

Screening for stress inducible selected heat shock gene and protein expression in embryonic stem cells isolated from cod (Gadus morhua) blastulas

Endre Steigum, Elisabeth Holen

Poster

2014

Bruk av LC-MS/MS for å karakterisere bioaktive peptider i Hpro®

Fiona Provan, Kjell Birger Øysæd, Marit Espe, Elisabeth Holen, Josef Daniel Rasinger, Eivind Larssen, Jørgen Seliussen

2002

Dietary nucleotides and human immune cells

Elisabeth Holen, Oddvin Bjørge, Roland Jonsson

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Elisabeth Holen

Publikasjoner

Faglige foredrag

Effekter av resveratrol på lipo-polysakkarid indusert transkripsjon av immungener og eikosanoidsekresjon i atlantisk laks, ved bruk av forskjellige cellemodeller.

In Vitro Fisk: Nye 3D modeller til ernæring og toksikologisk forskning.

Kan arginintilsetning påvirke forbrenning av visceralt fett gjennom økt polyaminomsetning i laks?

Do diets with 1-5% EPA and DHA induce inflammation in Atlantic salmon?

Allergimedisin svekker ikke immunforsvaret

Vitenskapelige artikler (NVI)

Effect of dietary replacement of fish meal with insect meal on in vitro bacterial and viral induced gene response in Atlantic salmon (Salmo salar) head kidney leukocytes

The effect of omega-3 and omega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cells

Development of a fatty liver model using oleic acid in primary liver cells isolated from Atlantic salmon and the prevention of lipid accumulation using metformin

Surplus arginine reduced lipopolysaccharide induced transcription of proinflammatory genes in Atlantic salmon head kidney cells

A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes

Choline supplementation increased total body lipid gain, while surplus methionine improved growth and amino acid retention in adult Atlantic salmon (Salmo salar)

Phytosterols are not involved in the development of fatty liver in plant oil fed Atlantic salmon (Salmo salar) at high or low water temperature

Choline supplementation to low methionine diets increase phospholipids in Atlantic salmon, while taurine supplementation had no effects on phospholipid status, but improved taurine status

β-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B4 secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation

Hydrolyzed fish proteins modulates both inflammatory and antioxidant gene expression as well as protein expression in a co culture model of liver and head kidney cells isolated from Atlantic salmon (Salmo salar)

Adult Atlantic salmon (Salmo salar L.) adapts to long-term surplus dietary arginine supplementation

Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells invitro

Hydrolyzed fish proteins reduced activation of caspase-3 in H 2 O 2 induced oxidative stressed liver cells isolated from Atlantic salmon (Salmo salar)

The impact of exogenous ω-6 and ω-3 polyunsaturated fatty acids on the induced production of pro- and anti-inflammatory prostaglandins and leukotrienes in Atlantic salmon head kidney cells using a full factorial design and LC-MS/MS

A co culture approach show that polyamine turnover is affected during inflammation in Atlantic salmon immune and liver cells and that arginine and LPS exerts opposite effects on p38MAPK signaling

Arginine supplementation and exposure time affects polyamine and glucose metabolism in primary liver cells isolated from Atlantic salmon

Aryl hydrocarbon receptor protein and Cyp1A1 gene induction by LPS and phenanthrene in Atlantic cod (Gadus morhua) head kidney cells

Methionine deficiency does not increase polyamine turnover through depletion of hepatic S-adenosylmethionine in juvenile Atlantic salmon

Cytokine gene expression and prostaglandin production in head kidney leukocytes isolated from Atlantic cod (Gadus morhua) added different levels of arachidonic acid and eicosapentaenoic acid

Taurine attenuates apoptosis in primary liver cells isolated from Atlantic salmon (Salmo salar)

Dietary arginine affects energy metabolism through polyamine turnover in juvenile Atlantic salmon (Salmo salar)

Low impact of exposure to environmentally relevant doses of Ra-226 in Atlantic cod (Gadus morhua) embryonic cells

Pathogen recognition and mechanisms in Atlantic cod (Gadus morhua) head kidney cells Bacteria (LPS) and virus (poly I:C) signals through different pathways and affect distinct genes

Application of Doehlert uniform shell designs for selecting optimal amounts of internal standards in the analysis of prostaglandins and leukotrienes by liquid chromatography-tandem mass spectrometry

Inhibition of p38 MAPK during cellular activation modulate gene expression of head kidney leukocytes isolated from Atlantic salmon (Salmo salar) fed soy bean oil or fish oil based diets

Ontogenetic expression of maternal and zygotic genes in Atlantic cod embryos under ambient and thermally stressed conditions

Development of a co-culture model for in vitro toxicological studies in Atlantic salmon

Transcriptional evidence for low contribution of oil droplets to acute toxicity from dispersed oil in first feeding Atlantic cod (Gadus morhua) larvae

Embryonic stem cells isolated from Atlantic cod (Gadus morhua) and the developmental expression of a stage-specific transcription factor ac-Pou2

Toxicological application of primary hepatocyte cell cultures of Atlantic cod (Gadus morhua) - Effects of BNF, PCDD and Cd

Pigmentation and eye-migration in Atlantic halibut (Hippoglossus hippoglossus L.) larvae: Relevance of knowledge on development of pigment cells and determination of body axes in vertebrates.

Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion

Dietary nucleotides and intestinal cell lines: I. Modulation of growth

Horfor øker hyppigheten av allergi i industrialiserte land mer enn i utviklingsland?

Evaluating B and T cell epitopes of ovomucoid: Intact modified molecules, CNBr fragments and synthetic peptides

Characterization of T cell response to a-lactalbumin in PMMC cultures from cow mild hypersensitivity adults

Annet tidsskriftbidrag

Enhanced polyamine turnover after arginine supplementation in an Atlantic salmon model-implications on growth and animal welfare

Methionine limitation-a threat to health? Using Atlantic salmon as the model

Rapporter og avhandlinger

Effekter av endret fettsyresammensetning i fôr til laks relatert til fiskens helse, velferd og robusthet (Fett for fiskehelse): Oppdatering 2016

Screening for stress inducible selected heat shock gene and protein expression in embryonic stem cells isolated from cod (Gadus morhua) blastulas

Poster

Bruk av LC-MS/MS for å karakterisere bioaktive peptider i Hpro®

Dietary nucleotides and human immune cells

β-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B₄ secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation