My current research focus is on investigating the role of the external environment, especially marine environment, in the emergence, transfer and selection of antibiotic-resistance. This includes microplastic associated pathogens and antibiotic resistance. I am currently having several projects on antibiotic resistance in the marine environment with external funding. My research also focuses on marine microbial ecology, with emphasis on microbial taxonomy (identification and characterization of novel species).
External Projects: KLEB-GAP : 2019-2023- Klebsiella pneumoniae - a key driver in the global spread of antimicrobial resistance and a target for new approaches in diagnostics, surveillance and alternative therapeutics (KLEB-GAP) - Project manager at IMR. Funding body- Trond Mohn Foundation.
Res-Marine : 2021-2024- Flushing into the ocean: Tracking antibiotic resistance in the marine environment- Researcher Project Young Research Talents grant recipient- Project manager / grant recipient- Research council of Norway.
BIOCIDE - 2021-2024- Antibacterial biocides in the water cycle - an integrated approach to assess and manage risks for antibiotic resistance development-JPI-Aquatic pollutants joint translational call 2020 - PI / Project manager- Norway.
Radisic, V., Lunestad, BT, Sanden, M., Bank, MS and Marathe, NP (2021) Draft Genome Sequence of Multidrug-Resistant Pseudomonas protegens Strain 11HC2, Isolated from Marine Plastic Collected from the West Coast of Norway. Microbiology resource announcements 10 (2), e01285-01220.
Radisic, V., Nimje, PS, Bienfait, AM and Marathe, NP (2020) Marine Plastics from Norwegian West Coast Carry Potentially Virulent Fish Pathogens and Opportunistic Human Pathogens Harboring New Variants of Antibiotic Resistance Genes. Microorganisms 8 (8), 1200.
Håkonsholm, F., Hetland, MA, Svanevik, CS, Sundsfjord, A., Lunestad, BT and Marathe, NP (2020) Antibiotic sensitivity screening of Klebsiella spp. And Raoultella spp. Isolated from marine bivalve molluscs reveal presence of CTX-M -producing K. pneumoniae. Microorganisms 8 (12), 1909.
Grevskott, DH, Salvà-Serra, F., Moore, ERB and Marathe, NP (2020) Nanopore sequencing reveals genomic map of CTX-M-type extendedspectrum β-lactamases carried by Escherichia coli strains isolated from blue mussels ( Mytilus edulis ) in Norway. BMC Microbiology 20, 134.
Böhm, M.-E., Razavi, M., Marathe, NP, Flach, C.-F. and Larsson, DJ (2020) Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities. Microbiome 8 (1), 1-11.
Fröhlich, C., Sørum, V., Huber, S., Samuelsen, O., Berglund, F., Kristiansson, E., Kotsakis, S. D., Marathe, N. P., Larsson, D. G. J., & Leiros S., H. K. (2020). Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. J Antimicrob Chemother, 75(9), 2554-2563.
Marathe NP, Berglund F, Razavi M, Pal C, Dröge J, Samant S, Kristiansson E, Larsson DJ: Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes. Microbiome 2019, 7 (1): 97.
Berglund F, Österlund T, Boulund F, Marathe NP, Larsson DJ, Kristiansson E: Identification and reconstruction of novel antibiotic resistance genes from metagenomes. Microbiome 2019, 7 (1): 52.
Walujkar SA, Kumbhare SV, Marathe NP, Patangia DV, Lawate PS, Bharadwaj RS, Shouche YS: Molecular profiling of mucosal tissue associated microbiota in patients manifesting acute exacerbations and remission stage of ulcerative colitis. World Journal of Microbiology and Biotechnology 2018, 34 (6): 76.
Marathe NP, Janzon A, Kotsakis SD, Flach CF, Razavi M, Berglund F, Kristiansson E, Larsson DJ: Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste. Environment international 2018, 112: 279-286.
Jutkina J, Marathe N, Flach CF, Larsson D: Antibiotics and common antibacterial biocides stimulate horizontal transfer of resistance at low concentrations. Science of the Total Environment 2018, 616: 172-178.
Razavi M, Marathe NP, Gillings MR, Flach CF, Kristiansson E, Larsson DJ: Discovery of the fourth mobile sulfonamide resistance gene. Microbiome 2017, 5 (1): 160.
Marathe NP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DJ: Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water research 2017, 124: 388-397.
Boulund F, Berglund F, Flach CF, Bengtsson-Palme J, Marathe NP, Larsson DJ, Kristiansson E: Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets. BMC Genomics 2017, 18 (1): 682.
Berglund F, Marathe NP, Österlund T, Bengtsson-Palme J, Kotsakis S, Flach CF, Larsson DJ, Kristiansson E: Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data. Microbiome 2017, 5 (1): 134.
Paul D, Kumbhare SV, Mhatre SS, Chowdhury SP, Shetty SA, Marathe NP, Bhute S, Shouche YS: Exploration of microbial diversity and community structure of lonar lake: the only hypersaline meteorite crater lake within basalt rock. Frontiers in microbiology 2016, 6: 1553.
Marathe NP, Shetty SA, Shouche YS, Larsson DJ: Limited bacterial diversity within a treatment plant receiving antibiotic-containing waste from bulk drug production. PloS one 2016, 11 (11): e0165914.
Marathe NP, Gaikwad SS, Vaishampayan AA, Rasane MH, Shouche YS, Gade WN: Mossambicus tilapia (Oreochromis mossambicus) collected from water bodies impacted by urban waste carries extended-spectrum beta-lactamases and integron-bearing gut bacteria. Journal of Biosciences 2016, 41 (3): 341-346.
Pandey PK, Verma P, Marathe N, Shetty S, Bavdekar A, Patole MS, Stensvold CR, Shouche YS: Prevalence and subtype analysis of Blastocystis in healthy Indian individuals. Infection, Genetics and Evolution 2015, 31: 296-299.
Marathe N, Nagarkar S, Vaishampayan A, Rasane M, Samant S, Dohe V, Kagal A, Shouche Y, Deshpande N: High prevalence of class 1 integrons in clinical isolates of methicillin-resistant Staphylococcus aureus from India. Indian journal of medical microbiology 2015, 33 (2): 231.
Lanjekar VB, Marathe NP, Shouche YS, Ranade DR: Clostridium punense sp. nov., an obligate anaerobic isolated from healthy human faeces. International Journal of Systematic and Evolutionary Microbiology 2015, 65 (12): 4749-4756.
Johnning A, Kristiansson E, Angelin M, Marathe N, Shouche YS, Johansson A, Larsson DJ: Quinolone resistance mutations in the faecal microbiota of Swedish travelers to India. BMC microbiology 2015, 15 (1): 235.
Walujkar SA, Dhotre DP, Marathe NP, Lawate PS, Bharadwaj RS, Shouche YS: Characterization of bacterial community shift in human Ulcerative Colitis patients revealed by Illumina based 16S rRNA gene amplicon sequencing. Gut Pathogens 2014, 6 (1): 22.
Rutgersson C, Fick J, Marathe N, Kristiansson E, Janzon A, Angelin M, Johansson A, Shouche Y, Flach CF, Larsson DJ: Fluoroquinolones and qnr genes in sediment, water, soil, and human fecal flora in an environment polluted by manufacturing discharges. Environmental Science & Technology 2014, 48 (14): 7825-7832.
Marathe NP, Shetty SA, Lanjekar VB, Rasane MH, Ranade DR, Shouche YS: Genome sequencing of multidrug resistant novel Clostridium sp. BL8 reveals its potential for pathogenicity. Good Pathogens 2014, 6 (1): 30.
Mahale KN, Paranjape PS, Marathe NP, Dhotre DP, Chowdhury S, Shetty SA, Sharma A, Sharma K, Tuteja U, Batra HV: Draft genome sequences of Yersinia pestis strains from the 1994 plague epidemic of Surat and 2002 Shimla outbreak in India . Indian Journal of Microbiology 2014, 54 (4): 480-482.
Lanjekar V, Marathe N, Ramana VV, Shouche Y, Ranade D: Megasphaera indica sp. nov., an obligate anaerobic bacteria isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology 2014, 64 (7): 2250-2256.
Shetty SA, Marathe NP, Shouche YS: Initiating exploration of the gut microbiome in Indians. Current Science 2013, 104 (5): 580.
Shetty SA, Marathe NP, Shouche YS: Opportunities and challenges for gut microbiome studies in the Indian population. Microbiome 2013, 1 (1): 24.
Shetty SA, Marathe NP, Lanjekar V, Ranade D, Shouche YS: Comparative genome analysis of Megasphaera sp. reveals niche specialization and its potential role in the human gut. PloS one 2013, 8 (11): e79353.
Marathe NP, Regina VR, Walujkar SA, Charan SS, Moore ER, Larsson DJ, Shouche YS: A treatment plant receiving waste water from multiple bulk drug manufacturers is a reservoir for highly multi-drug resistant integron-bearing bacteria. PLoS One 2013, 8 (10): e77310.
Marathe NP, Rasane MH, Kumar H, Patwardhan AA, Shouche YS, Diwanay SS: In vitro antibacterial activity of Tabernaemontana alternifolia (Roxb) stem bark aqueous extracts against clinical isolates of methicillin resistant Staphylococcus aureus. Annals of clinical microbiology and antimicrobials 2013, 12 (1): 26.
Marathe N, Shetty S, Lanjekar V, Ranade D, Shouche Y: Changes in human gut flora with age: an Indian familial study. BMC microbiology 2012, 12 (1): 222.
Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics
Marathe NP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DGJ
Discovery of the fourth mobile sulfonamide resistance gene
Razavi M, Marathe NP, Gillings MR, Flach C-F, Kristiansson E, Larsson DGJ
Mossambicus tilapia (Oreochromis mossambicus) collected from water bodies impacted by urban waste carries extended-spectrum beta-lactamases and integron-bearing gut bacteria
Nachiket P Marathe, Swapnil S Gaikwad, Ankita A Vaishampayan, Mandar H Rasane, Yogesh S Shouche, Wasudev N Gade
Journal of biosciences
Limited bacterial diversity within a treatment plant receiving antibiotic-containing waste from bulk drug production
Nachiket P Marathe, Sudarshan A Shetty, Yogesh S Shouche, DG Joakim Larsson
Rapporter og avhandlinger
Monitoring programme for veterinary control on seafood products imported to Norway from third countries – Results from 2020 - In accordance with Commission Regulation (EC) No 136/2004, Annex II, Part 1
Julia Endresen Storesund, Martin Wiech, Bjørn Tore Lunestad, Nachiket Prakash Marathe, Helge Torbjørn Hove
Monitoring programme for veterinary control on seafood products imported to Norway from third countries – Results from 2019: In accordance with Commission Regulation (EC) No 136/2004, Annex II, Part 1
Helge Torbjørn Hove, Julia Endresen Storesund, Bjørn Tore Lunestad, Nachiket Marathe, Martin Wiech